Table of Contents
Introduction
Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, remains a critical condition in adult healthcare. Early detection and intervention are crucial for improving survival rates. Identifying and monitoring specific biomarkers in blood, tissue, and other body fluids play a vital role in diagnosing and managing sepsis.
Common Sepsis Markers in Adults
The identification of sepsis markers is pivotal in the clinical setting to ascertain the presence and severity of sepsis. Here are some of the most common markers used in adults:
1. Procalcitonin (PCT)
Procalcitonin is a precursor of the hormone calcitonin, and its levels become elevated in response to a pro-inflammatory stimulus, especially of bacterial origin. An adult level greater than 0.5 ng/mL is often indicative of sepsis.
2. C-Reactive Protein (CRP)
CRP is a non-specific marker of inflammation that rises quickly in response to infection. Levels greater than 100 mg/L suggest significant inflammation, potentially indicating sepsis.
3. Lactate
Serum lactate levels are used to assess tissue hypoperfusion. Levels above 2 mmol/L can indicate sepsis and tissue hypoxia.
4. White Blood Cell Count (WBC)
An increase or decrease in the WBC count can be indicative of sepsis. Typically, a WBC count greater than 12,000/µL or less than 4,000/µL suggests sepsis.
5. Interleukin-6 (IL-6)
IL-6 is a cytokine that acts as both a pro-inflammatory and anti-inflammatory mediator. Elevated levels are often associated with sepsis and severity of illness.
Joinstar Company Solutions
Joinstar Biomedical Technology Co., Ltd. offers innovative solutions for the rapid detection of sepsis biomarkers, aiding in early diagnosis and timely intervention.
Joinstar PCT Rapid Test
This test quickly measures Procalcitonin levels in the blood, providing results within minutes to assess the likelihood of a bacterial infection leading to sepsis.
Joinstar CRP Rapid Test
Designed for point-of-care testing, this rapid test determines CRP levels, facilitating quick decisions on the presence of significant inflammation.
Comprehensive Sepsis Panel
Joinstar offers a comprehensive panel that includes multiple markers such as PCT, CRP, and IL-6, improving diagnostic accuracy through multiplex testing.
References
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Angus, D.C., & van der Poll, T. (2013). Severe Sepsis and Septic Shock. New England Journal of Medicine, 369(9), 840-851.
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Levy, M.M., et al. (2003). The Surviving Sepsis Campaign: Results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Medicine, 30(4), 536-553.
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Joinstar Biomedical Technology Co., Ltd. (2023). Product Catalog. Accessed at: [Insert URL]